Prediction of stable peptide binding to Class I HLAs is an important component for designing immunotherapies.While the best performing predictors are based on machine learning algorithms trained on peptide-HLA (pHLA) sequences, the use of structure for training predictors deserves further exploration.Given enough pHLA structures, a predictor based
The redundant manipulator can use redundant degree of freedom to avoid obstacles,but it does not affect the operation of the end effecter.So comparing with general non- redundant manipulator,the redundant manipulator has obvious advantages for dealing with obstacle avoidance.Recently,the space trajectory planning research of redundant manipulator h
Nothofagus alessandrii (ruil) is an endangered relict species, endemic to the Mediterranean area of Chile, and one of the most threatened trees in the country.Its natural distribution area has been greatly reduced by the effect of human activities; the remaining fragments are mostly intervened and highly deteriorated as a habitat and refuge for the
Abstract Background Anterior uveitis (AU) is the most frequent extra-articular feature of axial spondyloarthritis (axSpA).We aimed to assess and compare the incidence of AU in axSpA patients treated with anti-TNF or anti-IL17A.Methods We systematically reviewed PubMed, EMBase, and Cochrane from inception to May 3, 2020, and searched for placebo-con
In this digital era, social images are the most vital information copyright on multimedia social platforms.More and more users are interested in sharing social images with mobile terminals on multimedia social platforms.Social image sharing also faces potential risks from malicious use, such as illegal sharing, piracy, and misappropriation.This pap